Dissecting the role of calcium on collagen secretion in osteogenesis imperfecta
Scientific-Disciplinary Group
05/BIOS-07 - Biochemistry
Description
Collagen type I is the most abundant structural protein in the human body and its synthesis and secretion require tightly regulated endoplasmic reticulum (ER) function and intracellular calcium (Ca²⁺) homeostasis. Ca²⁺ is essential for collagen I folding, post- translational modification, ER stress signaling, and COPII-mediated export. The objective of this project is to investigate how alterations in ER and cytosolic Ca²⁺ concentration and dynamics affect collagen I trafficking and secretion. Using in vitro cellular models the study will (1) characterize ER and cytosolic Ca²⁺ levels and fluxes and (2) determine their impact onCOPII assembly and collagen I secretion.
Job posting website
Funding body
Università di Pavia
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