Study of the interaction between the human Thymidylate Synthase and its mRNA through singlemolecule force spectroscopy experiments

The researcher will be responsible for: synthesizing the molecules under investigation and optimizing their attachment to the surface of micrometer-sized polystyrene beads; using an optical tweezers instrument to optically manipulate individual RNA/protein molecules; realization of in-equilibrium and out-of-equilibrium force spectroscopy experiments; adjusting the physicochemical properties of the saline buffers used in the experiments; and analyzing experimental data using programs developed in MATLAB or Python

Selection process

The selection is carried out through the comparative evaluation of qualifications, scientific-professional curriculum, scientific productivity by a Selection Committee appointed by the Director of the structure. The Selection Committee shall be composed of three effective members, including the Scientific Supervisor and/or the Tutor, and at least one substitute member. - for qualifications 20 points: degree, PhD, specialization diploma, certificates of attendance of post-graduate specialisation courses (obtained in Italy or abroad);- for the scientific-professional curriculum 30 points: documented research activity carried out at public and private entities with contracts, scholarships or assignments (both in Italy and abroad) relevant to the research activity subject of the announcement;- for scientific productivity 10 points: quantity and quality of scientific publications, including master's or single-cycle master's or doctoral theses;- for the interview 40 points.

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