Role of Schwann cells within tumour microenvironment in liver cancer and melanoma

Study of the contribution of peripheral nerves to processes of neovascularisation associated with tumour growth, through structural, ultrastructural and immunohistochemical analyses in experimental models and in humans. The role of Schwann cells within the tumour microenvironment in liver cancer and melanoma will be analysed. The project will focus on the capacity of Schwann cells in modulating tumour angiogenesis and vascular mimicry which are essential steps in governing tumour growth, survival and invasion.